Measure ANS

Take control of surgical stress

Improve post op results

Surgical stress is the source of post op pain and many other complications which hemodynamics cannot to detect.

The ANITM and NIPETM offer a continuous and noninvasive measures of the sympathetic/parasympathetic balance from 26 months preterm to elderly, which leads to a more hemodynamic stability during anesthesia, less post op pain and better and faster recovery.

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Proven Intraop benefits for you and your patient


Helpful to diagnose the etiology
of a hemodynamic event

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Refine opioids titration

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Predict hemodynamic reactivity

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Proven Postop benefits for you and your patient


Predict post-extubation pain

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Reduce post-operative pain

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Reduce length of hospital stay

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technologies explained

Take control of surgical
stress with our products

ANIi & ANIm Trends

ANIm (averaged)

Percentage of the parasympathetic tone of the ANS in the last 4 minutes

ANIi (instantaneous)

Percentage of the parasympathetic  tone of the ANS in the last 2 minutes

Total variability of the RR signal (≈SDNN)

Graphical representation of the HFnu frequencies in 64 seconds


ANI monitor V2TM

Our workhorse stand-alone solution.  Robust against artifacts. Get more and better ANI measurements.

ANI MOC-9 moduleTM

Our integrated ANI measure into the Root device by Masimo. It enhances the performance of brain parameters to make them work cohesively

ANI monitor V1TM

Our classic standalone solution, with an internal battery and touch screen. This device will be discontinued soon.

Physidoloris Monitor V1TM

Our first ANI Monitor on the market.

ANI Sensor V1 & V1 PLUSTM




ANI-MR moduleTM

Our integration with Benevision Mindray monitors. It guides you with other measures of the triad to continuously lead you to better outcomes.

ANI Sensor V2TM



Dr. Jan Paul J Mulier Anesthesiologist

Department of Anaesthesiology & Intensive Care, AZ Sint-Jan Brugge KULeuven & UGent

I use daily the ANI monitor during my opioid-free anesthesia to titrate the non-opioid analgesic drugs. It allows me to reduce the dexmedetomidine and lidocaine dosages, which results in a faster and better awakening process of the patient as hemodynamics do not always reflect the surgical stress of the patient.

Dr. Pedro Gambus

Anesthesiologist, Hospital CLINIC de Barcelona

ANI offers the clinician the possibility to control vagal and parasympathetic activity in the operating room, critical care and perioperative setting in general. This is an important feature that we’ll be significantly more important in the future.

Dr. Bill Fawcett

Professor of Anaesthesia, Consultant anaesthesia/pain medicin, Guildford

At the heart of Enhanced Recovery After Surgery (ERAS) programs is the reduction in surgical stress. Whilst there are many approaches to this (such as minimally invasive surgery) a key area is excellent pain control. The ANI monitor allows objective intraoperative assessment of analgesia, permitting titrated pain control, optimizing patient analgesia and comfort and thus minimizing the stress response.

Dr. Pablo Ingelmo

Associate professor at McGill University and Director of Edwards Family Interdisciplinary Centre for Complex Pain, Montreal

Inadequate analgesia is associated with increases in the number of intraoperative and postoperative complications. However, nociception monitoring is currently not part of standard clinical care in anesthesia. ANI could be a useful tool to titrate medication to specific surgical stimulation allowing for a personalized use of analgesics during surgery.

Dr. Angel M. Gomez

Clinical Anesthesiologist - University of the Philippines

The objective measurement of pain is a much sought-after goal. Dr. Mathieu Jeanne proposed such a method 10 years ago, and this lead to the development of ANI. Looking at the autonomic nervous system responses with an emphasis on the parasympathetic. ANI guided analgesic delivery by reducing under or overdosing, thereby impacting patient outcomes in the operating room and ICU.

Dr. Luc Barvais

Head of cardiovascular anesthesia at Université Libre de Bruxelles

The monitoring of the heart rate variability according to a fixed respiratory rate in an anesthetized or sedated patient under controlled positive pressure ventilation is an important noninvasive pharmacodynamic parameter allowing the anesthetist or the intensivist to reduce remifentanil TCI or the opioid delivery.

Dr. Francisco Lobo

Staff Physician and the Director of Research in the Anesthesiology Institute at Cleveland Clinic Abu Dhabi

Guiding and titrating the hypnotic and antinociceptive components of propofol dexmedetomidine based on general anesthesia with spectral analysis of EEG (Masimo root monitor) and ANI: A modern way to go.

Dr. Rafael Cabrales

Staff Anesthesiologist at Cleveland Clinic Florida

Do we feel pain under anesthesia? Traditional heart rate, blood pressure response and depth of anesthesia monitoring don’t tell the whole picture of the body’s response to surgical stress. Trying out MDoloris Medical Systems today for the first time. All I can say is it’s a game changer. Now I can see real-time responses. No more guessing

Dr. Marusa Naranjo

Anesthesiologist at Clínica de Mérida, Mexico

The best biological signals to do amazing anesthesia. Security is the priority! Multimodal anesthesia technique with physiological control.

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