Measure ANS

Control nociception

Improve outcomes

In ICU and PICU there are patients requiring mechanical ventilation and sedation and overdosing is likely to happen due the long term administration and the characteristics of opioids.

The ANITM and NIPETM monitors offer continuous and noninvasive measures of the sympathetic/ parasympathetic balance allowing titration of analgesics.

Download the ICU brochure Download the PICU brochure

Proven benefits for you and your patient

Predict hemodynamic reactivity

Read the full study

Assessment of comfort

Read the full study

Predict post-extubation pain

Read the study

Diagnose the etiology of a haemodynamic event

Read the full study

technologies explained

Take control of stress
response with our products

ANIi & ANIm Trends

ANIm (averaged)

Percentage of the parasympathetic tone of the ANS in the last 4 minutes

ANIi (instantaneous)

Percentage of the parasympathetic  tone of the ANS in the last 2 minutes

Total variability of the RR signal (≈SDNN)

Graphical representation of the HFnu frequencies in 64 seconds


ANImonitor V2TM

Our workhorse stand-alone solution. Robust against artifacts. Get more and better ANI measurements.

ANI MOC-9 moduleTM

Our integrated ANI measure into the Root device by Masimo. It enhances the performance of brain parameters to make them work cohesively

ANI monitor V1TM

Our classic standalone solution, with an internal battery and touch screen. This device will be discontinued soon.

ANI-MR moduleTM

Our integration with Benevision Mindray monitors. It guides you with other measures of the triad to continuously lead you to better outcomes.

Dr. Angel Augusto Pérez Calatayud

Chief of Critical Area Division, Hospital General de México

The measurement of parasympathetic tone with ANI to continuously evaluate the level of analgesic comfort of the patient, optimizes the consumption of opiates, achieves adequate analgesia, and with a high negative predictive value that helps to differentiate the etiology of hemodynamic adverse events in the ICU mainly in patients under mechanical ventilation. It allows managing individualized doses to each patient managing to avoid sub or supratherapeutic doses, which has been of particular relevance during the COVID-19 pandemic due to the decrease in the supply of medicines for sedoanalgesia.

Dr. Carlos Chamorro Jambrina

Intensive Care Unit - Hospital Puerta de Hierro Majadahonda, Madrid

ANI monitor is very useful for monitoring the patient’s autonomic nervous system, especially in those undergoing mechanical ventilation, to titrate analgosedation.

Dr. Fabio Silvio Taccone

Head of ICU department at Hôpital Erasme, Belgium

We are implementing the use of ANI in our critically ill patients, in particular in those being unconscious and/or on muscle paralyzers. Ongoing studies will help to understand how ANI can be useful to estimated nociception in this setting

Dr. Rocio Tapia

Pediatric Intensivist at Hospital Ramón y Cajal, Madrid

I found the ANI and NIPE monitors extremely useful specially in the following siutations:

a) To easily and continuously monitor the comfort /distress balance in children.

b)To detect nociception in those patients without any alternative with scales like in deeply sedated and neuromuscular blocked patients.

DR. David Lozano Díaz

Pediatrician in Neonatal and Pediatric ICU at Hospital General La Mancha Centro, Ciudad Real

Using ANI and NIPE in my daily practice, I am able to titrate the analgesics more efficiently in my pediatric patients.

Dr. Tomas Lamas

Learning how to use ANI together with BIS to adjust sedation propofol and analgesic with remifentanil in patients with severe fascitis necrosis. This is very useful to titrate adequality those drugs to keep the patient comfortable.

All Solutions

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