Read this scholarly article published about how the definition of pain has changed after 40 years. Pain cannot be monitored in unconscious patients but surgical stress can be. Dr. Gray explains in this study that detecting pain is not the problem, but the inflammation produced by the response of the autonomic nervous system in unconscious patients in the ICU and/or the OR.

Mdoloris Medical System is helping physicians to measure the response of the autonomic nervous system to nociception so they can take control of surgical stress in order to improve the outcomes of the patient.